GEO series
The role of the transcriptional co-regulator Lmo4 in CD8+ T cell stemness, memory formation and antitumor immunity
GSE248171
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2024/07/24
GPL21626
Summary
We aimed to evaluate if Lmo4 is directly involved in the generation and preservation of stem cell-like T cells and if adoptively transferred Lmo4-overexpressing pmel-1 CD8+ T cells (which identify the shared melanoma-melanocyte differentiation antigen gp100) are therapeutically effective in mice bearing subcutaneous B16-hgp100 melanomas. Moreover, our purpose was to investigate the mechanisms by which Lmo4 regulates CD8+ T cell differentiation.
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Paper (PMID 39117617) ↗
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