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ZKSCAN3 promotes ovarian cancer cell proliferation through upregulating HSPB1

GSE248519 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/11/12 Platform GPL30209
Summary
Ovarian cancer has the worst prognosis in major gynecological cancers. Current therapies includes platinum, taxol, angiogenesis inhibitor, PARP inhibitor. However, most ovarian cancer patients develop resistance. Identification of more pro-tumor factors in ovarian cancer may shed insight into ovarian cancer biology and therapy. In this study, we find ZKSCAN3, a zinc-finger transcription factor is overexpressed in ovarian cancer. We show ZKSCAN3 promotes ovarian cancer cell proliferation. Through RNA-sequencing and ChIP-sequencing, HSPB1 is identified as a target gene of ZKSCAN3. HSPB1 expression is significantly decreased by suppressing ZKSCAN3. Suppressing HSPB1 expression inhibits ovarian cancer cell proliferation as well. In contrast, expressing exogenous HSPB1 partially rescues the cell proliferation in ZKSCAN3 knock-down cells. Collectively, our study uncovers a functional ZKSCAN3-HSPB1 axis that promotes ovarian cancer cell proliferation.
Published in
ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression
Ke Q, Li Z, Fan L et al. · Frontiers in molecular biosciences 2025 · PMID 41393507 · doi:10.3389/fmolb.2025.1623062
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Also filed as BioProject PRJNA1044418 and SRA study SRP473877. Searching any of these in the dataset finder brings you back here.

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