TAF1, the largest subunit of TFIID, is dispensable for adult hematopoiesis [RNA-Seq]
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 12 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TAF1 is required for fetal but not adult hematopoiesis in miceDevelopmental cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248654_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1045523 and SRA study SRP474371. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 12 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7918387 Control_Day0_1 Control_Day0
- GSM7918388 Control_Day0_2 Control_Day0
- GSM7918389 Control_Day0_3 Control_Day0
- GSM7918390 TAF1_KO_Day0_1 TAF1_KO_Day0
- GSM7918391 TAF1_KO_Day0_2 TAF1_KO_Day0
- GSM7918392 TAF1_KO_Day0_3 TAF1_KO_Day0
- GSM7918393 Control_Day3_1 Control_Day3
- GSM7918394 Control_Day3_2 Control_Day3
- GSM7918395 Control_Day3_3 Control_Day3
- GSM7918396 TAF1_KO_Day3_1 TAF1_KO_Day3
- GSM7918397 TAF1_KO_Day3_2 TAF1_KO_Day3
- GSM7918398 TAF1_KO_Day3_3 TAF1_KO_Day3
- GSM7918399 Control_Day5_Macrophage_1 Control_Day5_Macrophage
- GSM7918400 Control_Day5_Macrophage_2 Control_Day5_Macrophage
- GSM7918401 Control_Day5_Macrophage_3 Control_Day5_Macrophage
- GSM7918402 Control_Day5_Granulocyte_1 Control_Day5_Granulocyte
- GSM7918403 Control_Day5_Granulocyte_2 Control_Day5_Granulocyte
- GSM7918404 Control_Day5_Granulocyte_3 Control_Day5_Granulocyte
- GSM7918405 TAF1_KO_Day5_Macrophage_1 TAF1_KO_Day5_Macrophage
- GSM7918406 TAF1_KO_Day5_Macrophage_2 TAF1_KO_Day5_Macrophage
- GSM7918407 TAF1_KO_Day5_Macrophage_3 TAF1_KO_Day5_Macrophage
- GSM7918408 TAF1_KO_Day5_Granulocyte_1 TAF1_KO_Day5_Granulocyte
- GSM7918409 TAF1_KO_Day5_Granulocyte_2 TAF1_KO_Day5_Granulocyte
- GSM7918410 TAF1_KO_Day5_Granulocyte_3 TAF1_KO_Day5_Granulocyte
- GSM7918411 Control_Day7_Macrophage_1 Control_Day7_Macrophage
- GSM7918412 Control_Day7_Macrophage_2 Control_Day7_Macrophage
- GSM7918413 Control_Day7_Macrophage_3 Control_Day7_Macrophage
- GSM7918414 Control_Day7_Granulocyte_1 Control_Day7_Granulocyte
- GSM7918415 Control_Day7_Granulocyte_2 Control_Day7_Granulocyte
- GSM7918416 Control_Day7_Granulocyte_3 Control_Day7_Granulocyte
- GSM7918417 TAF1_KO_Day7_Macrophage_1 TAF1_KO_Day7_Macrophage
- GSM7918418 TAF1_KO_Day7_Macrophage_2 TAF1_KO_Day7_Macrophage
- GSM7918419 TAF1_KO_Day7_Macrophage_3 TAF1_KO_Day7_Macrophage
- GSM7918420 TAF1_KO_Day7_Granulocyte_1 TAF1_KO_Day7_Granulocyte
- GSM7918421 TAF1_KO_Day7_Granulocyte_2 TAF1_KO_Day7_Granulocyte
- GSM7918422 TAF1_KO_Day7_Granulocyte_3 TAF1_KO_Day7_Granulocyte
- GSE254025 The TFIID subunit Taf13 is dispensable for RNA polymerase II transcription, but essential for early embryogenesis 24 samples shares tfiid, taf1, dispensable, subunit
- GSE254023 The TFIID subunit Taf13 is dispensable for RNA polymerase II transcription, but essential for early embryogenesis (ChIP-Seq) 12 samples shares tfiid, taf1, dispensable, subunit
- GSE248657 TAF1 is required for fetal but not adult hematopoiesis in mice 60 samples shares taf1, hematopoiesis, adult
- GSE327228 RNA Terminal Uridylyl-Transferases Are Druggable Vulnerabilities in AML, but are Dispensable for Normal Hematopoiesis [RNA-seq] 27 samples shares hematopoiesis, dispensable, rna-seq
- GSE245195 Analysis of nascent transcription in ES cells mutant for specific TFIID subunits [4-sU-Seq] 11 samples shares tfiid, subunit
- GSE245196 Analysis of nascent transcription in ES cells mutant for specific TFIID subunits 55 samples shares tfiid, subunit
- GSE245194 Analysis of nascent transcription in ES cells mutant for specific TFIID subunits [CUT&Run] 36 samples shares tfiid, subunit
- GSE223673 Nr5a2 is dispensable for ZGA but essential for morula development [RNA-seq] 514 samples shares dispensable, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.