AMPK is necessary for Treg functional adaptation to microenvironmental stress during malignancy and viral pneumonia
RNA-seq (gene expression) · mouse · 41 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 41 samples: 5 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- AMPK is necessary for Treg functional adaptation to microenvironmental stress during malignancy and viral pneumoniaThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249017_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1047023 and SRA study SRP475140. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 25 samples.
How we read this: 5 replicated groups read from 41 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7925209 SplenocyteTreg_homeostasis_control_01, RNA-seq
- GSM7925210 SplenocyteTreg_homeostasis_control_02, RNA-seq
- GSM7925211 SplenocyteTreg_homeostasis_control_03, RNA-seq
- GSM7925212 SplenocyteTreg_homeostasis_control_04, RNA-seq
- GSM7925213 SplenocyteTreg_homeostasis_KO_01, RNA-seq
- GSM7925214 SplenocyteTreg_homeostasis_KO_02, RNA-seq
- GSM7925215 SplenocyteTreg_homeostasis_KO_03, RNA-seq
- GSM7925216 SplenocyteTreg_homeostasis_KO_04, RNA-seq
- GSM7925217 Day15_Treg_B16F10_control_01, RNA-seq
- GSM7925218 Day15_Treg_B16F10_control_02, RNA-seq
- GSM7925219 Day15_Treg_B16F10_control_03, RNA-seq
- GSM7925220 Day15_Treg_B16F10_control_04, RNA-seq
- GSM7925221 Day15_Treg_B16F10_control_05, RNA-seq
- GSM7925222 Day15_Treg_B16F10_KO_01, RNA-seq
- GSM7925223 Day15_Treg_B16F10_KO_02, RNA-seq
- GSM7925224 Day15_Treg_B16F10_KO_03, RNA-seq
- GSM8748063 Day12_Treg_B16F10_a1SKO_01 Day12_Treg_B16F10_a1SKO
- GSM8748064 Day12_Treg_B16F10_a1SKO_02 Day12_Treg_B16F10_a1SKO
- GSM8748065 Day12_Treg_B16F10_a1SKO_03 Day12_Treg_B16F10_a1SKO
- GSM8748066 Day12_Treg_B16F10_a1SKO_04 Day12_Treg_B16F10_a1SKO
- GSM8748067 Day12_Treg_B16F10_a2SKO_01 Day12_Treg_B16F10_a2SKO
- GSM8748068 Day12_Treg_B16F10_a2SKO_02 Day12_Treg_B16F10_a2SKO
- GSM8748069 Day12_Treg_B16F10_a2SKO_03 Day12_Treg_B16F10_a2SKO
- GSM8748070 Day12_Treg_B16F10_a2SKO_04 Day12_Treg_B16F10_a2SKO
- GSM8748071 Day12_Treg_B16F10_DKO_01 Day12_Treg_B16F10_DKO
- GSM8748072 Day12_Treg_B16F10_DKO_02 Day12_Treg_B16F10_DKO
- GSM8748073 Day12_Treg_B16F10_DKO_03 Day12_Treg_B16F10_DKO
- GSM8748074 Day12_Treg_B16F10_DKO_04 Day12_Treg_B16F10_DKO
- GSM8748075 Day12_Treg_B16F10_DKO_05 Day12_Treg_B16F10_DKO
- GSM8748076 Day12_Treg_B16F10_DKO_06 Day12_Treg_B16F10_DKO
- GSM8748077 Day12_Treg_B16F10_DKO_07 Day12_Treg_B16F10_DKO
- GSM8748078 Day12_Treg_B16F10_DKO_08 Day12_Treg_B16F10_DKO
- GSM8748079 Day12_Treg_B16F10_DKO_control_01 Day12_Treg_B16F10_DKO_c…
- GSM8748080 Day12_Treg_B16F10_DKO_control_02 Day12_Treg_B16F10_DKO_c…
- GSM8748081 Day12_Treg_B16F10_DKO_control_03 Day12_Treg_B16F10_DKO_c…
- GSM8748082 Day12_Treg_B16F10_DKO_control_04 Day12_Treg_B16F10_DKO_c…
- GSM8748083 Day12_Treg_B16F10_DKO_control_05 Day12_Treg_B16F10_DKO_c…
- GSM8748084 Day12_Treg_B16F10_DKO_control_06 Day12_Treg_B16F10_DKO_c…
- GSM8748085 Day12_Treg_B16F10_SKO_control_01 Day12_Treg_B16F10_SKO_c…
- GSM8748086 Day12_Treg_B16F10_SKO_control_02 Day12_Treg_B16F10_SKO_c…
+ 1 more — browse all 41 samples with per-sample file links →
- GSE266874 Pan AMPK-activator O304 ameliorates oxidative stress in MASLD, reverses lipid zonation and reveal lobular metabolic heterogeneitites in the murine live 30 samples shares ampk, stress
- GSE305462 Rac1 palmitoylation is required for cardiac stress adaptation and regulation of Protein Kinase A signaling 18 samples shares adaptation, stress
- GSE315845 Primary Cilia Mediate Stress Vulnerability and Exercise Antidepressant Adaptation: Evidence for Ventral Hippocampal Astrocytic Ciliary Remodeling by Exercise 9 samples shares adaptation, stress
- GSE293841 Rps15 mutation drives B cell malignancy through translational rewiring, oxidative stress and genomic instability 51 samples shares malignancy, stress
- GSE290022 Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 64 samples shares ampk
- GSE270826 AMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites 48 samples shares ampk
- GSE335135 CD36 gates nocturnal hypertension by regulating inactive period blood pressure variation via renal AMPK/HDAC5/PER1 axis 37 samples shares ampk
- GSE292517 AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon [RNAseq_AMPK_WheelRunning] 25 samples shares ampk
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.