H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium (CUT&Tag III)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 24 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H3K36 methylation regulates cell plasticity and regeneration in the intestinal epitheliumNature cell biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249087_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1047142 and SRA study SRP475165. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 12 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7926116 Ent, H3K36me3, rep1 Ent, H3K36me3,
- GSM7926117 Ent, H3K36me3, rep2 Ent, H3K36me3,
- GSM7926118 LGR5, H3K36me3, rep1 LGR5, H3K36me3,
- GSM7926119 LGR5, H3K36me3, rep2 LGR5, H3K36me3,
- GSM7926120 Pan, H3K36me3, rep1 Pan, H3K36me3,
- GSM7926121 Pan, H3K36me3, rep2 Pan, H3K36me3,
- GSM7926122 Tuft, H3K36me3, rep1 Tuft, H3K36me3,
- GSM7926123 Tuft, H3K36me3, rep2 Tuft, H3K36me3,
- GSM7926124 EE, H3K36me3, rep1 EE, H3K36me3,
- GSM7926125 EE, H3K36me3, rep2 EE, H3K36me3,
- GSM7926126 Gob, H3K36me3, rep1 Gob, H3K36me3,
- GSM7926127 Gob, H3K36me3, rep2 Gob, H3K36me3,
- GSM7926128 Ent, H3K27me3, rep1 Ent, H3K27me3,
- GSM7926129 Ent, H3K27me3, rep2 Ent, H3K27me3,
- GSM7926130 LGR5, H3K27me3, rep1 LGR5, H3K27me3,
- GSM7926131 LGR5, H3K27me3, rep2 LGR5, H3K27me3,
- GSM7926132 Pan, H3K27me3, rep1 Pan, H3K27me3,
- GSM7926133 Pan, H3K27me3, rep2 Pan, H3K27me3,
- GSM7926134 tuft, H3K27me3, rep1 tuft, H3K27me3,
- GSM7926135 tuft, H3K27me3, rep2 tuft, H3K27me3,
- GSM7926136 EE, H3K27me3, rep1 EE, H3K27me3,
- GSM7926137 EE, H3K27me3, rep2 EE, H3K27me3,
- GSM7926138 Gob, H3K27me3, rep1 Gob, H3K27me3,
- GSM7926139 Gob, H3K27me3, rep2 Gob, H3K27me3,
- GSE275296 H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium [cutandtag_enzyme_profiling] 12 samples shares h3k36, cut, regeneration, methylation, plasticity, intestinal, epithelium
- GSE229903 CUT&Tag analysis of H3K4me3, H3K27Ac,H2A119Ub, H3K27me3 and H3K36me3 in KPC1199 murine PDAC cell line 10 samples shares h3k36, cut
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares cut, plasticity
- GSE281926 Classes of Lamin-Associated Domains are Defined by Distinct Patterns of Repressive Histone Methylation [CUT&Tag] 18 samples shares cut, methylation
- GSE253201 Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis [CUT&RUN] 18 samples shares cut, methylation
- GSE292289 H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells 94 samples shares h3k36, methylation
- GSE297315 Crotonate-activated histone H3K14 crotonylation enhances intestinal regeneration after injury 41 samples shares regeneration, intestinal
- GSE338640 Vascular function underlies enhanced intestinal regeneration after FLASH radiation 26 samples shares regeneration, intestinal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.