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Investigating the noncanonical Nfkb2 pathway regulation of gene expression in modulating dendritic cell function.

GSE249101 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/11 Platform GPL24247
Summary
Dendritic cells (DCs) orchestrate intestinal inflammation in health and diseases. We found that human IBD was associated with heightened non-canonical NF-κB signaling in intestinal DCs. The non-canonical NF-κB pathway, which induces RelB:p52-mediated immune gene expressions, has been implicated in DC functions and that genetic inactivation of RelB:p52 in DCs alleviated experimental colitis in mice. Here, we aim to investigate the regulation of gene expression by noncanonical Nfkb2 pathway in modulating DC function.
Published in
Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
Deka A, Kumar N, Basu S et al. · The EMBO journal 2024 · PMID 39060515 · doi:10.1038/s44318-024-00182-6
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Also filed as BioProject PRJNA1047164 and SRA study SRP475198. Searching any of these in the dataset finder brings you back here.

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