Skeletal muscle expression profile changes in early stages of sepsis.

Purpose: RNA sequencing was employed to analyze the alterations in gene expression profiles within the gastrocnemius muscle of mice suffering from early sepsis.Methods: RNA sequencing was conducted on the gastrocnemius muscle of sepsis mice induced by LPS, as well as normal control mice.Results:The gene expression of the gastrocnemius muscle varied between early sepsis mice and normal control mice.Conclusions: Early sepsis mice exhibit significant differential gene expression in the gastrocnemius muscle, providing a promising avenue for early detection and treatment of sepsis-induced myopathy.