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Effect of Digoxin on clusters of circulating tumor cells in patients with metastatic breast cancer: a phase 1 trial

GSE249233 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/12/06 Platform GPL30173
Summary
The presence of circulating tumor cell (CTC) clusters is associated with disease progression, new metastasis formation and reduced survival in a variety of cancer types. In breast cancer, pre-clinical studies showed that inhibitors of the Na+/K+-ATPase can suppress CTC clusters shedding and block metastasis. Here, we conducted a prospective, open-label, phase I study in patients with metastatic breast cancer, where the primary endpoint was to determine whether a short (one week) treatment with the Na+/K+-ATPase inhibitor digoxin could reduce mean CTC cluster size. Mechanistically, transcriptome profiling of CTCs highlighted downregulation of cell-cell adhesion and cell cycle-related genes upon treatment with digoxin, in line with its cluster-dissolution activity. ClinicalTrials.gov identifier: NCT03928210.
Published in
Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial
Kurzeder C, Nguyen-Sträuli BD, Krol I et al. · Nature medicine 2025 · PMID 39856336 · doi:10.1038/s41591-024-03486-6
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Also filed as BioProject PRJNA1048069 and SRA study SRP475516. Searching any of these in the dataset finder brings you back here.

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