m6A alters ribosome dynamics to initiate mRNA degradation
RNA-seq (gene expression) · human · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 36 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- m(6)A alters ribosome dynamics to initiate mRNA degradationCell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249257_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1048343 and SRA study SRP585493. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 10 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7932273 wt_ctrl1 wt_ctrl
- GSM7932274 wt_ctrl2 wt_ctrl
- GSM7932275 wt_ctrl3 wt_ctrl
- GSM7932276 wt_starv1 wt_starv
- GSM7932277 wt_starv2 wt_starv
- GSM7932278 wt_starv3 wt_starv
- GSM7932279 ko_ctrl1 ko_ctrl
- GSM7932280 ko_ctrl2 ko_ctrl
- GSM7932281 ko_ctrl3 ko_ctrl
- GSM7932282 ko_starv1 ko_starv
- GSM7932283 ko_starv2 ko_starv
- GSM7932284 ko_starv3 ko_starv
- GSM8986459 wt_ctrl1 wt_ctrl
- GSM8986460 wt_ctrl2 wt_ctrl
- GSM8986461 wt_ctrl3 wt_ctrl
- GSM8986462 wt_emt1 wt_emt
- GSM8986463 wt_emt2 wt_emt
- GSM8986464 wt_emt3 wt_emt
- GSM8986465 ko_ctrl1 ko_ctrl
- GSM8986466 ko_ctrl2 ko_ctrl
- GSM8986467 ko_ctrl3 ko_ctrl
- GSM8986468 ko_emt1 ko_emt
- GSM8986469 ko_emt2 ko_emt
- GSM8986470 ko_emt3 ko_emt
- GSM8986471 siNC_ctrl_1 siNC_ctrl
- GSM8986472 siNC_ctrl_2 siNC_ctrl
- GSM8986473 siNC_ctrl_3 siNC_ctrl
- GSM8986474 siNC_emt_1 siNC_emt
- GSM8986475 siNC_emt_2 siNC_emt
- GSM8986476 siNC_emt_3 siNC_emt
- GSM8986477 siDFs_ctrl_1 siDFs_ctrl
- GSM8986478 siDFs_ctrl_2 siDFs_ctrl
- GSM8986479 siDFs_ctrl_3 siDFs_ctrl
- GSM8986480 siDFs_emt_1 siDFs_emt
- GSM8986481 siDFs_emt_2 siDFs_emt
- GSM8986482 siDFs_emt_3 siDFs_emt
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- GSE306977 Cell composition and gene-expression dynamics of skeletal muscle regeneration after contraction-induced injury 70 samples shares dynamics
- GSE270434 Bidirectional histone monoaminylation dynamics regulate neural rhythmicity 234 samples shares dynamics
- GSE261159 Gene expression dynamics of branching morphogenesis in pancreatic cancer organoids (2) 181 samples shares dynamics
- GSE134236 Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis 166 samples shares initiate
- GSE172333 A myeloid maturation program initiated by nucleotide depletion during S phase [RNA-Seq] 158 samples shares initiate
- GSE336954 Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder 126 samples shares dynamics
- GSE295336 H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics 77 samples shares dynamics
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.