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Neopetrotaurines A-C, Isoquinoline Alkaloids with an Unprecedented Taurine-Bridged Isoquinoline Quinone Moiety from the Sponge Neopetrosia sp.

GSE249431 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/21 Platform GPL18573
Summary
Neopetrotaurines A-C, isoquinoline quinone-linked isoquinoline alkaloids that possess a unique taurine bridge connecting the two bicyclic components, were isolated from a Neopetrosia sp. marine sponge. These new compounds have proton-deficient scaffolds, so their structure elucidation was facilitated by utilizing LR-HSQMBC and HMBC NMR experiments optimized to detect 4- and 5-bond long-range 1H-13C heteronuclear correlations. Neopetrotaurines A-C showed potent inhibition of transcription driven by the oncogenic fusion protein PAX3-FOXO1 in alveolar rhabdomyosarcoma.
Published in
Neopetrotaurines A-C, Isoquinoline Alkaloids with an Unprecedented Taurine Bridge from the Sponge Neopetrosia sp
Wang D, Jiang W, Churiwal M et al. · Journal of natural products 2024 · PMID 38294825 · doi:10.1021/acs.jnatprod.3c01041
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Also filed as BioProject PRJNA1049021 and SRA study SRP476075. Searching any of these in the dataset finder brings you back here.

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