Immune dysfunction mediated by the competitive endogenous RNA network in fetal side placental tissue of polycystic ovary syndrome
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249470_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1049348 and SRA study SRP476132. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7948618 C1miRNA
- GSM7948619 C2miRNA
- GSM7948620 C3miRNA
- GSM7948621 C4miRNA
- GSM7948622 C5miRNA
- GSM7948623 P1miRNA
- GSM7948624 P2miRNA
- GSM7948625 P3miRNA
- GSM7948626 P4miRNA
- GSM7948627 P5miRNA
- GSM7948628 C1ciRNA
- GSM7948629 C2ciRNA
- GSM7948630 C3ciRNA
- GSM7948631 C4ciRNA
- GSM7948632 C5ciRNA
- GSM7948633 P1ciRNA
- GSM7948634 P2ciRNA
- GSM7948635 P3ciRNA
- GSM7948636 P4ciRNA
- GSM7948637 P5ciRNA
- GSE261070 Dysfunctional neutrophil Type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization 134 samples shares dysfunction, mediated
- GSE311483 BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia 32 samples shares dysfunction, placental
- GSE252448 CCL2-mediated Endothelial Injury Drives Cardiac Dysfunction in Long COVID 23 samples shares dysfunction, mediated
- GSE250196 Endogenous aryl hydrocarbon receptor ligands-dysregulated transcriptomic profiles and endothelial function in human fetal endothelial cells 22 samples shares endogenous, fetal
- GSE338646 RNA-sequencing analysis of placental tissues from women with and without polycystic ovary syndrome 14 samples shares polycystic, placental
- GSE191067 Single-cell RNA-seq reveals the midkine-mediated immune microenvironment dysfunction in human keloids fibrotic niche 12 samples shares dysfunction, mediated
- GSE310264 Kaempferol Attenuates Spaceflight-associated Knee Cartilage Degeneration by Targeting NOX4-Mediated Mitochondrial Dysfunction 9 samples shares dysfunction, mediated
- GSE295760 Multi-omics of chorionic villus samples reveals early pregnancy placental dysfunction associated with preeclampsia 38 samples shares dysfunction, placental
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.