Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways [RNA-Seq II]
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related PathwaysAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249561_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1049487 and SRA study SRP476303. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7950045 IMR90_A485_rep1(RNA-seq)
- GSM7950046 IMR90_A485_rep2(RNA-seq)
- GSM7950047 IMR90_Control2_rep1(RNA-seq)
- GSM7950048 IMR90_Control2_rep2(RNA-seq)
- GSM7950049 IMR90_MS-275_rep1(RNA-seq)
- GSM7950050 IMR90_MS-275_rep2(RNA-seq)
- GSM7950051 IMR90_Control3_rep1(RNA-seq)
- GSM7950052 IMR90_Control3_rep2(RNA-seq)
- GSM7950058 Muscle_MS-275_rep1(RNA-seq)
- GSM7950059 Muscle_MS-275_rep2(RNA-seq)
- GSM7950060 Muscle_Control4_rep1(RNA-seq)
- GSM7950061 Muscle_Control4_rep2(RNA-seq)
- GSM8866211 Muscle_NALA_rep1(RNA-seq)
- GSM8866212 Muscle_NALA_rep2(RNA-seq)
- GSM8866213 Muscle_Control5_rep1(RNA-seq)
- GSM8866214 Muscle_Control5_rep2(RNA-seq)
- GSM8866215 IMR90_Pyruvate_rep1(RNA-seq)
- GSM8866216 IMR90_Pyruvate_rep2(RNA-seq)
- GSM8866217 IMR90_Control6_rep1(RNA-seq)
- GSM8866218 IMR90_Control6_rep2(RNA-seq)
- GSE226006 Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways [CUT&Tag] 32 samples shares aging-related, lactylation, antagonizes, senescence, modulating, skeletal, histone
- GSE285826 SenCat: Redefining human cell senescence 232 samples shares senescence
- GSE295888 SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging. 30 samples shares senescence
- GSE245949 Failed reprogramming of transformed cells due to induction of apoptosis and senescence impairs tumor progression in lung cancer 24 samples shares senescence
- GSE304030 oHSV-mediated JAG1 blockade induces glioma senescence-associated secretory phenotype to increase macrophage activation and sensitize to cetuximab-mediated senolysis 24 samples shares senescence
- GSE270175 Oxysterol Sensing through GPR183 Triggers Endothelial Senescence and Cardio-renal Injuries via Altering Circadian Signaling in Hypertension 18 samples shares senescence
- GSE282283 YAP activation reverses aging-related visual dysfunction caused by impaired cell-matrix adhesion 15 samples shares aging-related
- GSE269652 SP1 antagonizes H3K27me3 to shape chromatin landscapes for RNA polymerase II recruitment during gastrulation 106 samples shares antagonizes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.