Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 32 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 32 samples: 32 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related PathwaysAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226006_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA938243 and SRA study SRP424331. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 32 sample titles: 32 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7061592 IMR90_Senescent_rep1(CUT&Tag)
- GSM7061593 IMR90_Senescent_rep2(CUT&Tag)
- GSM7061594 IMR90_Young_rep1(CUT&Tag)
- GSM7061595 IMR90_Young_rep2(CUT&Tag)
- GSM7061596 IMR90_Hypoxia_rep1(CUT&Tag)
- GSM7061597 IMR90_Hypoxia_rep2(CUT&Tag)
- GSM7061598 IMR90_Normoxia_rep1(CUT&Tag)
- GSM7061599 IMR90_Normoxia_rep2(CUT&Tag)
- GSM7329321 IMR90_2-DG_rep1(CUT&Tag)
- GSM7329322 IMR90_2-DG_rep2(CUT&Tag)
- GSM7329323 IMR90_Control1_rep1(CUT&Tag)
- GSM7329324 IMR90_Control1_rep2(CUT&Tag)
- GSM8866191 IMR90_Pyruvate(CUT&Tag)
- GSM8866192 IMR90_Control6(CUT&Tag)
- GSM8866193 IMR90_A485_lac(CUT&Tag)
- GSM8866194 IMR90_MS-275_lac(CUT&Tag)
- GSM8866195 IMR90_Control_lac(CUT&Tag)
- GSM8866196 IMR90_A485_ace(CUT&Tag)
- GSM8866197 IMR90_MS-275_ace(CUT&Tag)
- GSM8866198 IMR90_Control_ace(CUT&Tag)
- GSM8866199 Muscle_MS-275_rep1(CUT&Tag)
- GSM8866200 Muscle_MS-275_rep2(CUT&Tag)
- GSM8866201 Muscle_Control4_rep1(CUT&Tag)
- GSM8866202 Muscle_Control4_rep2(CUT&Tag)
- GSM8866203 Muscle_Aging_rep1(CUT&Tag)
- GSM8866204 Muscle_Aging_rep2(CUT&Tag)
- GSM8866205 Muscle_Young_rep1(CUT&Tag)
- GSM8866206 Muscle_Young_rep2(CUT&Tag)
- GSM8866207 Muscle_Running_rep1(CUT&Tag)
- GSM8866208 Muscle_Running_rep2(CUT&Tag)
- GSM8866209 Muscle_Sedentary_rep1(CUT&Tag)
- GSM8866210 Muscle_Sedentary_rep2(CUT&Tag)
- GSE249561 Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways [RNA-Seq II] 20 samples shares aging-related, lactylation, antagonizes, senescence, modulating, skeletal, histone
- GSE283531 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [RNA-Seq] 54 samples shares cut, histone
- GSE283096 The histone acetyltransferase MOZ is a molecular dependency and therapeutic target in NUP98-rearranged acute myeloid leukemia [WGS, ATACseq, CUT&RUN, scRNAseq] 38 samples shares cut, histone
- GSE241304 TET2 regulates histone H2AK119ub and leukemogenesis through LTR RNA m5C oxidation [seq_DNA-CUTandTag] 24 samples shares cut, histone
- GSE289448 DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [CUT&RUN] 21 samples shares cut, skeletal
- GSE218716 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [ChIP-Seq/Cut&Run-Seq] 156 samples shares cut
- GSE253753 Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia 126 samples shares cut
- GSE295715 Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness 90 samples shares cut
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.