Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 6 × CD8+ T cells, Vehicle, vs 6 × CD8+ T cells, CGRP, vs 2 × patient vs 2 × healthy individualGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sensory neuroimmune signaling in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysisThe Journal of allergy and clinical immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249576_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1049746 and SRA study SRP476244. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 8 as controls.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7924575 CD8+ T cells, Vehicle, rep1 CD8+ T cells, Vehicle,
- GSM7924576 CD8+ T cells, Vehicle, rep2 CD8+ T cells, Vehicle,
- GSM7924577 CD8+ T cells, Vehicle, rep3 CD8+ T cells, Vehicle,
- GSM7924578 CD8+ T cells, Vehicle, rep4 CD8+ T cells, Vehicle,
- GSM7924579 CD8+ T cells, Vehicle, rep5 CD8+ T cells, Vehicle,
- GSM7924580 CD8+ T cells, Vehicle, rep6 CD8+ T cells, Vehicle,
- GSM7924581 CD8+ T cells, CGRP, rep1 CD8+ T cells, CGRP,
- GSM7924582 CD8+ T cells, CGRP, rep2 CD8+ T cells, CGRP,
- GSM7924583 CD8+ T cells, CGRP, rep3 CD8+ T cells, CGRP,
- GSM7924584 CD8+ T cells, CGRP, rep4 CD8+ T cells, CGRP,
- GSM7924585 CD8+ T cells, CGRP, rep5 CD8+ T cells, CGRP,
- GSM7924586 CD8+ T cells, CGRP, rep6 CD8+ T cells, CGRP,
- GSM7949323 patient 1 patient
- GSM7949324 patient 2 patient
- GSM7949325 healthy individual 1 healthy individual
- GSM7949326 healthy individual 2 healthy individual
- GSE242543 Calcitonin gene-related peptide promotes reparative function of interleukin-4 educated human macrophages via COX1/PGD2 signalling 12 samples shares gene-related, calcitonin, peptide
- GSE332711 CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV 60 samples shares cd8, induced
- GSE328788 Inhibition of programmed cell death-1 in cytotoxic CD8+ T cells exacerbates pressure overload-induced cardiac injury 14 samples shares cd8, induced
- GSE274788 X-ray-induced more serious damage to CD8+ T cells in patients with hypopharyngeal squamous cell carcinoma (HPSCC) than those in healthy individuals 12 samples shares cd8, induced
- GSE210231 CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance 931 samples shares cd8, induced
- GSE289829 Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells 31 samples shares cd8, induced
- GSE279781 CD137 agonism enhances anti-PD1 induced activation of clonally expanded CD8+ T cells in a neoadjuvant pancreatic cancer clinical trial 30 samples shares cd8, induced
- GSE306620 TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells 26 samples shares cd8, induced
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.