Research on the Mechanism of PTEN Mediated tumor-associated macrophages (TAMs) Polarization
RNA-seq (gene expression) · mouse · 46 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 46 samples: 34 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppressionDevelopmental cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249577_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1049748 and SRA study SRP475665. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 46 sample titles: 34 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7932564 C1,PBS
- GSM7932565 C2,PBS
- GSM7932566 C3,PBS
- GSM7932567 P1,PTEN
- GSM7932568 P2,PTEN
- GSM7932569 P3,PTEN
- GSM7932570 CON_CON_1
- GSM7932571 CON_CON_2
- GSM7932572 CON_CON_3
- GSM7932573 CON_CON_4
- GSM7932574 CON_PTEN_1
- GSM7932575 CON_PTEN_2
- GSM7932576 CON_PTEN_3
- GSM7932577 CON_PTEN_4
- GSM7932578 F_CON_1
- GSM7932579 F_CON_2
- GSM7932580 F_CON_3
- GSM7932581 F_CON_4
- GSM7932582 F_PTEN_1
- GSM7932583 F_PTEN_2
- GSM7932584 F_PTEN_3
- GSM7932585 F_PTEN_4
- GSM7932586 N1_C,PBS
- GSM7932587 N1_P,PTEN
- GSM7932588 N2_C,PBS
- GSM7932589 N2_P,PTEN
- GSM7932590 N3_C,PBS
- GSM7932591 N3_P,PTEN
- GSM7932592 N4_C,PBS
- GSM7932593 N4_P,PTEN
- GSM7932594 S11_C,PBS
- GSM7932595 S11_P,PTEN
- GSM7932596 S12_C,PBS
- GSM7932597 S12_P,PTEN
- GSM7932598 S13_C,PBS
- GSM7932599 S13_P,PTEN
- GSM7932600 S14_C,PBS
- GSM7932601 S14_P,PTEN
- GSM7932602 S21_C,PBS
- GSM7932603 S21_P,PTEN
+ 6 more — browse all 46 samples with per-sample file links →
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares tumor-associated, macrophages
- GSE325329 Transcriptomic profiling of macrophages that phagocytosed apoptotic Treg or conventional CD4⁺ T (Tconv) cells under different polarization conditions [RNA-Seq] 28 samples shares polarization, macrophages
- GSE237783 Complex interaction of tumor-derived factors instructs the niche specific phenotypes of tumor-associated macrophages [RNA-Seq] 28 samples shares tumor-associated, macrophages
- GSE324935 IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to promote antitumor immunity in melanoma 20 samples shares tumor-associated, macrophages
- GSE285794 Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion 12 samples shares tumor-associated, macrophages
- GSE271267 Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases 12 samples shares tumor-associated, macrophages
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares tumor-associated, macrophages
- GSE250056 Targeting chemokine crosstalk between T-cells and macrophages to treat immune checkpoint inhibito-mediated myocarditis 68 samples shares macrophages, mediated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.