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Single-cell CRISPRi transcriptome screening focusing on a subset of lncRNAs regulated by hypoxia

GSE249597 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/11 Platform GPL30173
Summary
In order to gain new insights into the molecular functions of 6 hypoxia-regulated lncRNAs in LUAD cells we performed a single-cell CRISPRi transcriptome screening based on the CROP-Seq approach.
Published in
Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural network
Truchi M, Lacoux C, Gille C et al. · Frontiers in bioinformatics 2024 · PMID 38501112 · doi:10.3389/fbinf.2024.1340339
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Also filed as BioProject PRJNA1049792 and SRA study SRP476441. Searching any of these in the dataset finder brings you back here.

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