Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery
RNA-seq (gene expression) · human · 135 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 135 samples: 135 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recoveryNature cardiovascular research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249697_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1050197 and SRA study SRP476676. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 135 sample titles: 135 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7957474 Pat14.BL-1
- GSM7957475 Pat1.BL-1
- GSM7957476 Pat59.BL-1
- GSM7957477 Pat3.BL-1
- GSM7957478 Pat50.BL-1
- GSM7957479 Pat45.BL-1
- GSM7957480 Pat11.BL-1
- GSM7957481 Pat51.BL-1
- GSM7957482 Pat80.BL-1
- GSM7957497 Pat-33-preBL
- GSM7957498 Pat-72-preBL
- GSM7957499 Pat-91-preBL
- GSM7957500 Pat-33-FU
- GSM7957501 Pat-72-FU
- GSM7957502 Pat-91-FU
- GSM7957523 Pat 54-BL
- GSM7957524 Pat 42-BL
- GSM7957525 Pat 22-BL
- GSM7957526 Pat 35-BL
- GSM7957527 Pat 40-BL
- GSM7957528 Pat 38-BL
- GSM7957529 Pat 27-BL
- GSM7957530 Pat 24-BL
- GSM7957531 Pat 74-BL
- GSM7957532 Pat 46-BL
- GSM7957533 Pat 14-BL
- GSM7957534 Pat 78-BL
- GSM7957535 Pat 25-BL
- GSM7957536 Pat 96-BL
- GSM7957537 Pat 5-BL
- GSM7957538 Pat 43-BL
- GSM7957539 Pat 62-BL
- GSM7957540 Pat 67-BL
- GSM7957541 Pat 92-BL
- GSM7957542 Pat 79-BL
- GSM7957543 Pat 57-BL
- GSM7957544 Pat 44-BL
- GSM7957545 Pat 66-BL
- GSM7957546 Pat 97-BL
- GSM7957547 Pat 34-BL
+ 95 more — browse all 135 samples with per-sample file links →
- GSE208592 Characterization of DNA methylation changes associated with lung and right ventricle dysfunction in pulmonary hypertension 33 samples shares hypertension, pulmonary, ventricle, changes
- GSE228133 Deficiency of Smooth Muscle ADAR1 RNA Editing Exacerbates Vascular Remodeling and Pulmonary Hypertension [pul43_RNA-seq] 12 samples shares hypertension, remodeling, pulmonary
- GSE335339 PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension [BID-seq] 20 samples shares hypertension, remodeling, pulmonary
- GSE254617 Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. 148 samples shares hypertension, pulmonary
- GSE325715 Gene expression in patients with pulmonary hypertension due to valve heart disease 146 samples shares hypertension, pulmonary
- GSE303084 Pressure Points: Endothelial Responses to Hemodynamic Stress in Health and Pulmonary Arterial Hypertension 72 samples shares hypertension, pulmonary
- GSE289930 Proteogenomic Characterization of Primary Oral Cancer Unveils Extracellular Matrix Remodeling and Immunosuppressive Microenvironment Linked to Lymph Node Metastasis [RNA-seq] 33 samples shares extracellular, remodeling
- GSE309392 Cancer-associated fibroblasts promote esophageal carcinogenesis and lung metastasis by CDH11-mediated extracellular matrix environment remodeling [scRNA-Seq] 23 samples shares extracellular, remodeling
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.