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LXR agonism promotes T cell effector chromatin landscapes upon crosspriming by dendritic cells.

GSE249707 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/12/29 Platform GPL21103
Summary
Here, we assess chromatin accessibility profiles of OT-I CD8+ T cells upon co-culture with antigen-pulsed BMDCs in the presence or absence of the synthetic LXR agonist RGX-104.
Published in
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
Ostendorf BN, Goldstein JG, Liu S et al. · The Journal of experimental medicine 2026 · PMID 41665603 · doi:10.1084/jem.20252290
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Also filed as BioProject PRJNA1050214 and SRA study SRP476632. Searching any of these in the dataset finder brings you back here.

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