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Use of azithromycin may impair fetal growth via causing ER stress in placental syncytiotrophoblasts

GSE249788 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/01 Platform GPL24676
Summary
Azithromycin (AZM) is widely used to treat perinatal mycoplasma infection in pregnancy. The use of AZM is thought to have few adverse consequences. However, emerging evidence indicates that AZM may have potential adverse effects on pregnancy outcomes. Here, we explored whether AZM might affect pregnancy outcomes by influencing placental function. To investigate the effects of azithromycin on human placenta trophoblast, Transcriptomic sequencing was conducted to screen the genes and biological pathways influenced by AZM in cultured human placental trophoblasts
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Direct links to NCBI, no account and no request form: the whole study as GSE249788_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1050589 and SRA study SRP476797. Searching any of these in the dataset finder brings you back here.

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