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Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus [ds1]

GSE249795 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/07/19 Platform GPL17021
Summary
To profile neurogenesis in the adult mouse hippocampus, we utilized a strategy to isolate developing cells derived from RGLs expressing the proneural gene Achaete-scute homolog 1 (Ascl1). Tamoxifen administration to young-adult Ascl1CreERT2;CAGfloxStopSun1sfGFP mice were used to induce the expression of Sun1-sfGFP in the nuclear membrane of RGLs and permanently label their progeny. This birthdating tag enabled a comprehensive analysis of the entire process encompassing neuronal differentiation, development, and functional maturation. This dataset was built using FACS-sorted nuclei obtained from dentate gyri microdissected at 1-, 2-, 4-, and 8 weeks after TAM induction (cohorts w1 through w8)
Published in
Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus
Rasetto NB, Giacomini D, Berardino AA et al. · Science advances 2024 · PMID 39028813 · doi:10.1126/sciadv.adp6039
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Also filed as BioProject PRJNA1050599 and SRA study SRP476812. Searching any of these in the dataset finder brings you back here.

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