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Single cell RNA seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice

GSE249839 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/11/13 Platform GPL21273
Summary
Patients surviving a septic episode exhibit persistent immune impairment and increased mortality due to enhanced infection vulnerability. In the present study, using the cecal ligation and puncture (CLP) model of polymicrobial sepsis, we addressed the hypothesis that functional, metabolic, and phenotypic alterations in splenic CD11b+Ly6Chigh myeloid cells contribute to the immune impairment in sepsis-surviving mice. Herein, we showed the cellular and transcriptional heterogeneity of the expanded splenic CD11b+Ly6Chigh population in CLP-survivors. We also showed that CD11b+Ly6Chigh cells presented phenotypic and functional disparity between C57BL6/J and BALB/c strains.
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Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b(+)Ly6C(high) monocyte population expanded in sepsis-surviving mice
Watanabe H, Rana M, Son M et al. · Molecular medicine (Cambridge, Mass.) 2024 · PMID 39506629 · doi:10.1186/s10020-024-00970-0
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Also filed as BioProject PRJNA1050991 and SRA study SRP477260. Searching any of these in the dataset finder brings you back here.

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