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Effect of tRF-1-Ser on the gene expression of breast cancer cell MDA-MB-453

GSE249937 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/15 Platform GPL24676
Summary
tRNA-derived small RNAs (tsRNA) are a new type of noncoding RNAs that can be mainly classified into two groups: tRFs (tRNA-derived fragments) and tiRNAs (tRNA halves). The abnormal expression of tsRNAs is known to play an important role in the biological progression of breast cancer. However, it's still unclear about the mechanism of tsRNAs in cancer. tRF-1-Ser is a tRF that is high expression in breast cancer and negatively regulated by 25(OH)D. Our study aims to find out the effect of tRF-1-Ser on breast cancer and explore the change of RNA in tRF-1-Ser knock-down breast cancer cells.
Published in
A 3'-pre-tRNA-derived small RNA tRF-1-Ser regulated by 25(OH)D promotes proliferation and stemness by inhibiting the function of MBNL1 in breast cancer
Wan X, Shi W, Ma L et al. · Clinical and translational medicine 2024 · PMID 38725048 · doi:10.1002/ctm2.1681
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Also filed as BioProject PRJNA1051151 and SRA study SRP477396. Searching any of these in the dataset finder brings you back here.

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