GEO series
Dependence of RBPJ genomic binding on the formation of macromolecular complexes
GSE249973
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
54 samples
2025/01/08
GPL24676
Summary
RBPJ is the central transcription factor involved in the Notch-dependent transcriptional response. Ist repressive function is strongly dependent on its interaction with the corepressor SHARP. Here we analyzed the gomic binding of RBPJ wt, and different RBPJ mutants making use of RBPJ or SHARP depleted HeLa cells. and
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Paper (PMID 39893191) ↗
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