MLL1 histone methyltransferase and UTX histone demethylase functionally cooperate to regulate the expression of NRF2 in response to ROS-induced oxidative stress
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 21 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MLL1 histone methyltransferase and UTX histone demethylase functionally cooperate to regulate the expression of NRF2 in response to ROS-induced oxidative stressFree radical biology & medicine · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250128_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1052074 and SRA study SRP477834. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7974252 HaCaT, Input, Untreated
- GSM7974253 HaCaT, MLL1, Untreated
- GSM7974254 HaCaT, MLL1, 100 uM H2O2
- GSM7974255 HaCaT, UTX, Untreated
- GSM7974256 HaCaT, UTX, 100 uM H2O2
- GSM7974257 HaCaT, H3K4me3, Untreated
- GSM7974258 HaCaT, H3K4me2, 100 uMH2O2
- GSM7974259 HaCaT, H3K27me3, Untreated
- GSM7974260 HaCaT, H3K27me3, 100 uM H2O2
- GSM7974261 shControl, Untreated
- GSM7974262 shControl, 100 uM H2O2
- GSM7974263 shControl, 25 ug/mL CeO2 NP
- GSM7974264 shMLL1, Untreated
- GSM7974265 shMLL1, 100 uM H2O2
- GSM7974266 shMLL1, 25 ug/mL CeO2 NP
- GSM7974267 shUTX, Untreated
- GSM7974268 shUTX, 100 uM H2O2
- GSM7974269 shUTX, 25 ug/mL CeO2 NP
- GSM7974270 shNRF2, Untreated
- GSM7974271 shNRF2, 100 uM H2O2
- GSM7974272 shNRF2, 25 ug/mL CeO2 NP
- GSE250127 Gene expression profiles under oxidative stress conditions in human HaCaT keratinocytes and the derivative cells expressing shRNA against NRF2, MLL1, or UTX. 12 samples shares mll1, nrf2, utx
- GSE300505 The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN [ChIP-seq] 37 samples shares methyltransferase, cooperate
- GSE300512 The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN [RNA-seq] 23 samples shares methyltransferase, cooperate
- GSE241566 Reversal of high-glucose-induced transcriptional and epigenetic memories through NRF2 pathway activation 29 samples shares nrf2
- GSE301298 Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency 88 samples shares utx
- GSE212452 EZH2 reads DNA 6mA to regulate survival and drug resistance of human head and neck squamous carcinoma by suppressing RIOX2-CDKN1A-NRF2 signaling axis 42 samples shares nrf2
- GSE293361 Genetic Alterations in KEAP1-NRF2 system Induced by Anti-Cancer Treatments Contribute to Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma 42 samples shares nrf2
- GSE301297 Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency [RNA-seq] 40 samples shares utx
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.