← BioTransfer GEO Dataset Finder
GEO series

Radiation-induced amphiregulin drives tumor metastases

GSE250375 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/27 Platform GPL24247
Summary
In this study, we demonstrate that radiation induces the epidermal growth factor receptor (EGFR) ligand amphiregulin (AREG) in tumor cells, which stimulates distant metastasis proliferation in both patients and pre-clinical murine tumor models. Using single-cell RNAseq (sc-RNAseq), we characterized the effects of AREG-induction on immune cells in the lung metastatic microenvironment of B6 mice.
Published in
Radiation-induced amphiregulin drives tumour metastasis
Piffkó A, Yang K, Panda A et al. · Nature 2025 · PMID 40369065 · doi:10.1038/s41586-025-08994-0
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE250375_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1053776 and SRA study SRP478465. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.