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Suppression of the mRNA export pathway dampens viral mimicry response and promotes tumor immune evasion

GSE250591 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 118 samples Submitted 2025/06/01 Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 118 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
118 samples: 48 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcriptsScience translational medicine · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcripts
Wang X, Jin J, Yan H et al. · Science translational medicine 2025 · PMID 40203080 · doi:10.1126/scitranslmed.ado4370
This dataset
Open GSE250591 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250591_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1054582 and SRA study SRP521001. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40203080) ↗
Study design
48 conditions, mostly in duplicate
Carm1-knockout B16-F10 cells, sgCtrl, ×4 Carm1-knockout B16-F10 cells Cytoplasm, sgCtr… ×4 Carm1-knockout B16-F10 cells Nuclear, sgCtrl, ×4 B16-F10 cells, sgCtrl treated with Decitabine, ×4 B16-F10 cells Cytoplasm, sgCtrl treated with … ×4 B16-F10 cells Nuclear, sgCtrl treated with De… ×4 B16-F10 cells, wild-type, input, ×4 B16-F10 cells, Carm1-knockout, input, ×4 +46 more

Supports a case/control comparison: 39 samples read as cases, 31 as controls.

How we read this: 48 replicated groups read from 118 sample titles; they account for 112 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 78 more — browse all 118 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.