Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional bursting
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 63 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 63 samples: 63 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional burstingiScience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE251654_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1055009 and SRA study SRP479140. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 63 sample titles: 63 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7984579 EtOH-1-ERa-Cut&TAG
- GSM7984580 EtOH-2-ERa-Cut&TAG
- GSM7984581 EtOH-3-ERa-Cut&TAG
- GSM7984582 E2-1-ERa-Cut&TAG
- GSM7984583 E2-2-ERa-Cut&TAG
- GSM7984584 E2-3-ERa-Cut&TAG
- GSM7984585 BPA-1-ERa-Cut&TAG
- GSM7984586 BPA-2-ERa-Cut&TAG
- GSM7984587 BPA-3-ERa-Cut&TAG
- GSM7984588 EtOH-1-FoxA1-Cut&TAG
- GSM7984589 EtOH-2-FoxA1-Cut&TAG
- GSM7984590 EtOH-3-FoxA1-Cut&TAG
- GSM7984591 E2-1-FoxA1-Cut&TAG
- GSM7984592 E2-2-FoxA1-Cut&TAG
- GSM7984593 E2-3-FoxA1-Cut&TAG
- GSM7984594 BPA-1-FoxA1-Cut&TAG
- GSM7984595 BPA-2-FoxA1-Cut&TAG
- GSM7984596 BPA-3-FoxA1-Cut&TAG
- GSM7984597 EtOH-1-27ac-Cut&TAG
- GSM7984598 EtOH-2-27ac-Cut&TAG
- GSM7984599 EtOH-3-27ac-Cut&TAG
- GSM7984600 E2-1-27ac-Cut&TAG
- GSM7984601 E2-2-27ac-Cut&TAG
- GSM7984602 E2-3-27ac-Cut&TAG
- GSM7984603 BPA-1-27ac-Cut&TAG
- GSM7984604 BPA-2-27ac-Cut&TAG
- GSM7984605 BPA-3-27ac-Cut&TAG
- GSM7984606 EtOH-1-MED1-Cut&TAG
- GSM7984607 EtOH-2-MED1-Cut&TAG
- GSM7984608 EtOH-3-MED1-Cut&TAG
- GSM7984609 E2-1-MED1-Cut&TAG
- GSM7984610 E2-2-MED1-Cut&TAG
- GSM7984611 E2-3-MED1-Cut&TAG
- GSM7984612 BPA-1-MED1-Cut&TAG
- GSM7984613 BPA-2-MED1-Cut&TAG
- GSM7984614 BPA-3-MED1-Cut&TAG
- GSM7984615 EtOH-1b-ATAC
- GSM7984616 EtOH-2b-ATAC
- GSM7984617 EtOH-3b-ATAC
- GSM7984618 E2-1b-ATAC
+ 23 more — browse all 63 samples with per-sample file links →
- GSE251649 Altered Cofactor Recruitment and Nucleosome Dynamics Underlie Bisphenol A's Impact on Estrogen Receptor-Mediated Transcriptional Bursting [CUT&Tag] 45 samples shares recruitment, nucleosome, bisphenol, cofactor, dynamics, underlie, mediated, bursting
- GSE288140 HDAC2-Mediated Recruitment of METTL3 to Chromatin Regulates Human Embryonic Stem Cell Differentiation 74 samples shares recruitment, mediated
- GSE314395 HIF-1–Mediated PPME1 Expression Promotes Breast Cancer Progression via AKT Activation and β-Catenin Recruitment 24 samples shares recruitment, mediated
- GSE274688 The lineage master transcription factor, p63 recruits a cancer-specific cofactor, FOXK1 to mediate oncogenic 3D chromatin dynamics in squamous cell carcinoma [RNA-seq] 22 samples shares cofactor, dynamics
- GSE274411 The lineage master transcription factor, p63 recruits a cancer-specific cofactor, FOXK1 to mediate oncogenic 3D chromatin dynamics in squamous cell carcinoma[ATAC-seq] 16 samples shares cofactor, dynamics
- GSE292648 Nucleosome dynamics render heterochromatin generally accessible in living human cells (qDA seq in MCF7 nuclei in buffer without spermidine) 10 samples shares nucleosome, dynamics
- GSE334805 Aptamer-Mediated Multivalent Endogenous ADAR1 Recruitment for Highly Efficient RNA Editing 9 samples shares recruitment, mediated
- GSE274413 The lineage master transcription factor, p63 recruits a cancer-specific cofactor, FOXK1 to mediate oncogenic 3D chromatin dynamics in squamous cell carcinoma [ChIP-seq] 8 samples shares cofactor, dynamics
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.