Tofogliflozin Attenuates Renal Lipid Deposition and Inflammation via PPARα restoration in Diet-induced Steatohepatitic mice
Non-coding RNA profiling · mouse · 12 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic miceEndocrine journal · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE251739_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1055144 and SRA study SRP479268. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7987152 NASH1 (RNA-Seq)
- GSM7987153 NASH2 (RNA-Seq)
- GSM7987154 NASH3 (RNA-Seq)
- GSM7987155 NASHTofo1 (RNA-Seq)
- GSM7987156 NASHTofo2 (RNA-Seq)
- GSM7987157 NASHTofo3 (RNA-Seq)
- GSM7987158 NASH1 (miRNA-Seq)
- GSM7987159 NASH2 (miRNA-Seq)
- GSM7987160 NASH3 (miRNA-Seq)
- GSM7987161 NASHTofo1 (miRNA-Seq)
- GSM7987162 NASHTofo2 (miRNA-Seq)
- GSM7987163 NASHTofo3 (miRNA-Seq)
- GSE315007 Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice. 30 samples shares ppar, diet-induced
- GSE328603 Hepatic FoxO3 Supports Metabolic Resilience, Attenuates Age-Associated Obesity and Metabolic Dysfunction, and Mitigates Diet-Induced Steatohepatitis 12 samples shares diet-induced, attenuates
- GSE282998 Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse livers 192 samples shares ppar
- GSE314029 An unimolecular GIPR:GLP-1R:PPAR , , quintuple agonist eliminates obesity and insulin resistance in mice. 159 samples shares ppar
- GSE319608 Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy 98 samples shares ppar
- GSE303717 Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism 56 samples shares ppar
- GSE302948 Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior [BulkSeq] 48 samples shares ppar
- GSE277188 Decoding the YAP/TAZ–PPARγ Regulatory Axis in Adipocyte Differentiation and Dedifferentiation [ChIP-seq] 46 samples shares ppar
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.