Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice.
RNA-seq (gene expression) · mouse · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 30 samples: 6 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sex- and hepatocyte PPAR(γ)-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in micebioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE315007_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1394781 and SRA study SRP658354. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 6 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9420027 M-LF-C-1 M-LF-C
- GSM9420028 M-LF-C-2 M-LF-C
- GSM9420029 M-LF-C-3 M-LF-C
- GSM9420030 M-LF-C-4 M-LF-C
- GSM9420031 F-LF-C-1 F-LF-C
- GSM9420032 F-LF-C-2 F-LF-C
- GSM9420033 F-LF-C-3 F-LF-C
- GSM9420034 F-LF-C-4 F-LF-C
- GSM9420035 F-LF-C-5 F-LF-C
- GSM9420036 M-HF-C-1 M-HF-C
- GSM9420037 M-HF-C-2 M-HF-C
- GSM9420038 M-HF-C-3 M-HF-C
- GSM9420039 M-HF-C-4 M-HF-C
- GSM9420040 M-HF-C-5 M-HF-C
- GSM9420041 M-HF-C-6 M-HF-C
- GSM9420042 F-HF-C-1 F-HF-C
- GSM9420043 F-HF-C-2 F-HF-C
- GSM9420044 F-HF-C-3 F-HF-C
- GSM9420045 F-HF-C-4 F-HF-C
- GSM9420046 F-HF-C-5 F-HF-C
- GSM9420047 M-HF-KO-1 M-HF-KO
- GSM9420048 M-HF-KO-2 M-HF-KO
- GSM9420049 M-HF-KO-3 M-HF-KO
- GSM9420050 M-HF-KO-4 M-HF-KO
- GSM9420051 M-HF-KO-5 M-HF-KO
- GSM9420052 F-HF-KO-1 F-HF-KO
- GSM9420053 F-HF-KO-2 F-HF-KO
- GSM9420054 F-HF-KO-3 F-HF-KO
- GSM9420055 F-HF-KO-4 F-HF-KO
- GSM9420056 F-HF-KO-5 F-HF-KO
- GSE338380 Hepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housing 48 samples shares diet-induced, hepatocyte
- GSE291082 Hepatocyte-specific Angiotensinogen Deficiency Inhibits Western Diet-induced Liver Steatosis With Suppression of Cell Division in Mice 23 samples shares diet-induced, hepatocyte
- GSE270246 Hepatic insulin resistance promotes fructose-enriched diet-induced fatty liver diseases. 22 samples shares diet-induced, fructose
- GSE293050 RNA-seq results in the liver of male hepatocyte-specific GAPDH knockout mice in fasting supplemented with or without serine 6 samples shares supplemented, hepatocyte
- GSE19038 Germfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism 30 samples shares diet-induced, cholesterol
- GSE309251 Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction 347 samples shares diet-induced
- GSE283692 A ketogenic diet and voluntary exercise modify the sciatic nerve and gastrocnemius transcriptome in diet-induced obese mice 96 samples shares diet-induced
- GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares diet-induced
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.