GEO series
Mutant NPM1 marginally impacts ribosome footprint in acute myeloid leukemia cells
GSE251919
Homo sapiens
Expression profiling by high throughput sequencing; Other
12 samples
2024/09/30
GPL20301
Summary
Combining RNA-seq, Ribo-seq and selective NPM1c degradation through dTAG-13, we explored for the first time the impact of NPM1c on ribosome footprint in the two available NPM1-mutated cell lines. Analysis of translatome showed that NPM1c only marginally impacts ribosome abundance and positioning on mRNA in NPM1-mutated cells.
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Paper (PMID 39415917) ↗
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