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Transcriptome analysis for the effect of Trichostatin A on intrahepatic cholangiocarcinoma cells

GSE252094 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/20 Platform GPL11154
Summary
Trichostatin A (TSA) is a commonly used antifungal drug characterized by inhibiting the activity of histone deacetylases (HDACs). As an antineoplastic agent, the pharmacological actions of TSA includes: 1. Inhibiting the proliferation of tumor cells directly; 2. Promoting the antitumor effect of immune cells; 3. Enhancing the efficacy of other antitumor drugs. The efficacy of TSA in the treatment of intrahepatic cholangiocarcinoma (ICCA) is still unknown and needs further verification. Therefore, in this study, ICCA cell line HUCCT1 was treated by TSA. The total RNA samples were used for transcriptome analysis to find the potential target of HDACs.
Published in
Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
Xiong F, Wang D, Xiong W et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 38812060 · doi:10.1186/s13046-024-03070-3
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Direct links to NCBI, no account and no request form: the whole study as GSE252094_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1057777 and SRA study SRP480275. Searching any of these in the dataset finder brings you back here.

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