GEO series
The effect of myeloid STING knockout on gene expression in colitic mice
GSE252100
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/08/14
GPL24247
Summary
Myeloid-derived STING has been recognized to play a vital role in mediating the development of colitis. We here report that myeloid-specific knockout of STING in adult mice ameliorates DSS-induced acute colitis through inhibiting macrophage maturation, reducing DC cell activation, and suppressing pro-inflammatory Th1 and Th17 cells.
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Paper (PMID 39113810) ↗
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