Differentiation of T-regulatory type 1 cells into an immunoregulatory Foxp3+ subset distinct from conventional FoxP3+ T-regulatory cells
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BLIMP-1-dependent differentiation of T follicular helper cells into Foxp3(+) T regulatory type 1 cellsFrontiers in immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252235_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1058984 and SRA study SRP480620. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 11 more — browse all 11 samples with per-sample file links →
- GSE237146 Expression profiling of tumor-infiltrating CD4+ FOXP3- conventional T cells from tumors of wildtype and Foxp3-Cre x CK2b-fl/fl mice 10 samples shares foxp3, conventional, type
- GSE263830 Effect of Sin3a deletion on gene expression within FoxP3+ T-regulatory cells 12 samples shares foxp3, t-regulatory
- GSE306145 Bulk RNA sequencing of quadricep in wildtype and Foxp3-DTR mice in synthetic material implant fibrosis 10 samples shares foxp3, type
- GSE291030 Context-dependent regulation of T follicular helper cell formation, expansion and differentiation into T-regulatory type 1 cells by multiple transcription factors 15 samples shares t-regulatory, type
- GSE305064 FOXP3 Expression Depends on Cell-Type Specific Cis-Regulatory Element and Transcription Factor Circuitry [mouse_Tconv_ChIP-seq] 15 samples shares foxp3, type
- GSE249261 Selective Regulation of a Defined Subset of Inflammatory and Immunoregulatory Genes by an NF-kB p50-IkBz Pathway 136 samples shares immunoregulatory, subset
- GSE248152 Comprehensive mapping of epigenetic events during the T-follicular helper-to-T-regulatory type-1 transdifferentiation pathway reveal a global poised state 31 samples shares t-regulatory, type
- GSE314783 Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response 17 samples shares conventional, type
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.