A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
RNA-seq (gene expression) · human · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 23 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A myeloid trisomy 21-associated gene variant is protective from Alzheimer's diseaseNature neuroscience · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252238_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1058989 and SRA study SRP480623. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 6 as controls.
How we read this: 7 replicated groups read from 23 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7997911 CAGG_A455D
- GSM7997912 CAGG_WT_rep1 CAGG_WT
- GSM7997913 CAGG_WT_rep2 CAGG_WT
- GSM7997914 CAGG_WT_rep3 CAGG_WT
- GSM7997915 DS_A455D_rep1 DS_A455D
- GSM7997916 DS_A455D_rep2 DS_A455D
- GSM7997917 DS_A455D_rep3 DS_A455D
- GSM7997918 DS_WT_rep1 DS_WT
- GSM7997919 DS_WT_rep2 DS_WT
- GSM7997920 WT_A455D_rep1 WT_A455D
- GSM7997921 WT_A455D_rep2 WT_A455D
- GSM7997922 WT_A455D_rep3 WT_A455D
- GSM7997923 WT_WT_rep1 WT_WT
- GSM7997924 WT_WT_rep2 WT_WT
- GSM7997925 DS A455D PMPs transplanted, Cont-tau treated
- GSM7997926 DS A455D PMPs transplanted, DSAD-tau treated
- GSM7997927 WT A455D PMPs and CAGG WT PMPs co-transplanted, Cont-tau treated
- GSM7997928 WT A455D PMPs and CAGG WT PMPs co-transplanted, DSAD-tau treated, replication 1 WT A455D PMPs and CAGG …
- GSM7997929 WT A455D PMPs and CAGG WT PMPs co-transplanted, DSAD-tau treated, replication 2 WT A455D PMPs and CAGG …
- GSM8606171 DS A455D PMPs transplanted, DSAD-tau treated, 10 mo, rep 1 DS A455D PMPs transplan…
- GSM8606172 DS A455D PMPs transplanted, DSAD-tau treated, 10 mo, rep 2 DS A455D PMPs transplan…
- GSM8607474 ND20 CR5 iPSC WGS
- GSM8607475 CAGG WT ESC WGS
- GSE243750 SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE 288 samples shares alzheimer
- GSE274037 A microglia clonal inflammatory disorder in Alzheimer’s Disease 54 samples shares alzheimer
- GSE152277 G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT 30 samples shares myeloid
- GSE233208 Single-nucleus RNA-Seq and spatial transcriptomics characterization of Alzheimer’s Disease and Down Syndrome 185 samples shares alzheimer
- GSE172333 A myeloid maturation program initiated by nucleotide depletion during S phase [RNA-Seq] 158 samples shares myeloid
- GSE283531 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [RNA-Seq] 54 samples shares myeloid
- GSE274229 Evolution of myeloid-mediated immunotherapy resistance in prostate cancer 52 samples shares myeloid
- GSE324329 A kidney-protective mechanism via cellular oxidative stress reduction induced by CD5L protein 38 samples shares protective
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.