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RNA sequencing of CTOT19 transplantation patients, and single-cell RNA sequencing of PBMC with and without LILRB3-4SNPs pretransplant and posttransplant

GSE252274 Homo sapiens (human) Single-cell RNA-seq 235 samples Submitted 2024/12/26 Platform GPL30173Platform GPL24676Platform GPL18573
At a glance

Single-cell RNA-seq · human · 235 samples

What it is
Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
Organism
Homo sapiens (human)
Samples
235 samples: 130 × V vs 77 × baselineLIL vs 2 × PBMCGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
LILRB3 genetic variation is associated with kidney transplant failure in African American recipientsNature medicine · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C et al. · Nature medicine 2025 · PMID 40065170 · doi:10.1038/s41591-025-03568-z
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252274_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA1059051 and SRA study SRP480738. Searching any of these in the dataset finder brings you back here.

Study design
130 × V vs 77 × baselineLIL vs 2 × PBMC

Supports a between-group comparison across 209 samples.

How we read this: 3 replicated groups read from 235 sample titles; they account for 209 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 195 more — browse all 235 samples with per-sample file links →

Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.