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RNA sequencing of CTOT19 transplantation patients [bulk RNA-seq]

GSE252272 Homo sapiens (human) RNA-seq (gene expression) 130 samples Submitted 2024/12/26 Platform GPL30173
At a glance

RNA-seq (gene expression) · human · 130 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
130 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
LILRB3 genetic variation is associated with kidney transplant failure in African American recipientsNature medicine · 2025
Summary (written by the submitters)
The CTOT19 cohort (38.2% AA, 44% White) represents a randomized controlled trial investigating the efficacy of remicade induction therapy for deceased donor kidney transplant recipients within 2 year followed-up (NCT02495077). With a cohort of 225 patients, the study spanned 2 years to assess the effectiveness of this therapy.
Published in
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C et al. · Nature medicine 2025 · PMID 40065170 · doi:10.1038/s41591-025-03568-z
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252272_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1059145 and SRA study SRP480738. Searching any of these in the dataset finder brings you back here.

Study design
A cohort of 130 individual samples

The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Sample titles run VR-0336 … VR-0850 and carry no group information.

Samples in this study

+ 90 more — browse all 130 samples with per-sample file links →

Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.