Novel culture systems for naive human embryonic stem cells based on chemical molecule screening
DNA methylation · human · 26 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stabilityProtein & cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252316_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1059630 and SRA study SRP480814. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 26 more — browse all 26 samples with per-sample file links →
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares chemical, stem
- GSE201709 Multiomic profiling of vascular endothelial cell differentiation from human embryonic stem cells 130 samples shares embryonic, stem
- GSE328191 Multiomic profiling of vascular endothelial cell differentiation from human embryonic stem cells [ChIP-seq] 80 samples shares embryonic, stem
- GSE288140 HDAC2-Mediated Recruitment of METTL3 to Chromatin Regulates Human Embryonic Stem Cell Differentiation 74 samples shares embryonic, stem
- GSE249035 Sex-biased Gene Expression During Neural Differentiation of Human Embryonic Stem Cells 72 samples shares embryonic, stem
- GSE293514 Development of a split-toxin CRISPR screening platform to systematically identify upstream regulators of human myoblast fusion 57 samples shares screening, stem
- GSE245986 Profiling circular RNAs across human embryonic stem cell differentiation identifies the role of circACVR2A(4-6) in neuroectoderm lineage differentiation. 54 samples shares embryonic, stem
- GSE238256 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor 51 samples shares chemical, molecule
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.