Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant tolerance
Single-cell RNA-seq · mouse · 16 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant toleranceThe Journal of clinical investigation · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252337_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1060247 and SRA study SRP481012. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7999672 Accept kidney allografts, total cells, integrated of 1 & 3 & 24 weeks, scRNAseq
- GSM7999673 Accept recipient spleen, total cells, integrated of 1 & 3 & 24 weeks, scRNAseq
- GSM7999674 Accept kidney grafts, 1 week, total cell, scRNAseq
- GSM7999675 Accept kidney grafts, 3 week, total cell, scRNAseq
- GSM7999676 Accept kidney grafts, 24 week, total cell, scRNAseq
- GSM7999677 Rejecting kidney grafts, 1 week, total cell, scRNAseq
- GSM7999678 Naive spleen, total cell, scRNAseq
- GSM7999679 Accept kidney grafts, 1 week, CD8 T cell, scRNAseq
- GSM7999680 Accept kidney grafts, 3 week, CD8 T cell, scRNAseq
- GSM7999681 Accept kidney grafts, 24 week, CD8 T cell, scRNAseq
- GSM7999682 Accept recipient spleen, 1 week, CD8 T cell, scRNAseq
- GSM7999683 Accept recipient spleen, 3 week, CD8 T cell, scRNAseq
- GSM7999684 Accept recipient spleen, 24 week, CD8 T cell, scRNAseq
- GSM7999685 Rejecting kidney grafts, 1 week, CD8 T cell, scRNAseq
- GSM7999686 Rejecting recipient spleen, 1 week, CD8 T cell, scRNAseq
- GSM7999687 Naive spleen, CD8 T cell, scRNAseq
- GSE316541 α2,6-Sialoglycan-regulated anti-tumor immunity of tumor-infiltrating CD8+ T cells in the tumor microenvironment [CD8+T] 27 samples shares cd8, infiltrating
- GSE207029 Blockade of avb8 integrin synergizes with checkpoint inhibition to enhance anti-tumor immunity through Cxcl9-dependent augmentation of CD8+ T cell cytotoxicity 12 samples shares cd8, cytotoxic
- GSE316540 α2,6-Sialoglycan-regulated anti-tumor immunity of tumor-infiltrating CD8+ T cells in the tumor microenvironment 9 samples shares cd8, infiltrating
- GSE157232 The CD8+ T cell tolerance checkpoint triggers a transcriptionally and epigenetically distinct differentiation state defined by protein translation defects 30 samples shares cd8, tolerance
- GSE270050 Expansion of Tumor-Infiltrating CD8+ T Cell Clonotypes Occurs in the Spleen in Response to Immune Checkpoint Blockade 29 samples shares cd8, infiltrating
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. 12 samples shares dysfunction, promotes
- GSE296763 Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 99 samples shares cd8
- GSE302682 Sleeping Beauty mutagenesis identifies BACH2 and other regulators promoting CD8+ T cell persistence and effector function under tumor-associated chronic antigen stimulation - RNAseq 66 samples shares cd8
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.