Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction.
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × homeostasis vs 4 × inflammation vs 4 × resolutionGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The distinct transcriptomic signature of the resolution phase fibroblast-like synoviocytes supports endothelial cell dysfunctionCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289751_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1224443 and SRA study SRP564234. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8798051 homeostasis_1 homeostasis
- GSM8798052 homeostasis_2 homeostasis
- GSM8798053 homeostasis_3 homeostasis
- GSM8798054 homeostasis_4 homeostasis
- GSM8798055 inflammation_1 inflammation
- GSM8798056 inflammation_2 inflammation
- GSM8798057 inflammation_3 inflammation
- GSM8798058 inflammation_4 inflammation
- GSM8798059 resolution_1 resolution
- GSM8798060 resolution_2 resolution
- GSM8798061 resolution_3 resolution
- GSM8798062 resolution_4 resolution
- GSE316731 Endothelial Cell-specific Activation of NOX1 Drives Obesity and Metabolic Syndrome via Skeletal Muscle Mitochondrial Dysfunction with Novel Genetic Signatures 12 samples shares endothelial, dysfunction, signature
- GSE285475 Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction 18 samples shares endothelial, dysfunction
- GSE261224 Brain endothelial cells with inflammatory signature in CCM disease in hypoxia and normoxia conditions 18 samples shares endothelial, signature
- GSE296698 Vascular Cell Senescence and Age-Related Endothelial Dysfunction: The Role of the Senescence-Associated Secretory Phenotype and CXCL12 15 samples shares endothelial, dysfunction
- GSE245987 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart] 4 samples shares endothelial, dysfunction
- GSE192687 Single-cell RNAseq analysis of renal endothelial cells in murine diabetic nephropathy 5464 samples shares endothelial
- GSE274544 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [scRNA-Seq] 1494 samples shares endothelial
- GSE229427 Tracking spatio-temporal dynamics of the endothelial niche during fetal hematopoiesis 216 samples shares endothelial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.