Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252400_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1060334 and SRA study SRP480958. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 18 more — browse all 18 samples with per-sample file links →
- GSE240887 The intellectual disability risk gene Kdm5b regulates long term memory consolidation in the hippocampus 44 samples shares intellectual, disability
- GSE267989 Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease 27 samples shares ameliorates, synaptic
- GSE213745 Disruption of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation in the brain and impairs memory 15 samples shares intellectual, disability
- GSE294445 Modulation of non-canonical WNT5B-NFATc2 pathway-dependent MMP14 expression in astrocytes ameliorates neuropathology and motor behaviors in Huntington's disease mice 9 samples shares ameliorates, modulation
- GSE313803 HNRNPH2 variant linked to intellectual disability disrupts myelination by impairing oligodendrocyte differentiation 7 samples shares intellectual, disability
- GSE44746 Loss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability 21 samples shares intellectual, disability
- GSE290539 Chronic administration of a HDAC inhibitor boosts microglial differentiation and treats neurological disease in a mouse model of intellectual disability. 16 samples shares intellectual, disability
- GSE276761 IL-10-dependent Treg-microglia crosstalk induced by nasal anti-CD3 mAb ameliorates traumatic brain injury by modulating microglial phagocytosis and neuroinflammation. 136 samples shares ameliorates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.