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Multifactoral Immune Modulation Potentiates Durable Remission in Multiple Models of Aggressive Malignancy

GSE252411 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/20 Platform GPL24247
Summary
Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate adaptive responses and contribute to escape from immune surveillance. Given the variety of mechanisms involved in shielding tumors from immune recognition, it is not surprising that single agent immunomodulatory approaches have been largely unsuccessful in generating durable antitumor responses. Here we report a unique combination of immunomodulatory and cytostatic agents that recondition the tumor microenvironment and eliminate complex and/or poor-prognosis tumor types including the aggressive MOC-2 model of HNSCC. scRNAseq analysis implicated up-regulation of innate immune responses and antigen presentation in tumor cells and the myeloid cell compartment as critical early events.
Published in
Multifactoral immune modulation potentiates durable remission in multiple models of aggressive malignancy
Halpert MM, Burns BA, Rosario SR et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 · PMID 38738472 · doi:10.1096/fj.202302675R
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Also filed as BioProject PRJNA1060422 and SRA study SRP480992. Searching any of these in the dataset finder brings you back here.

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