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Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

GSE252511 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/14 Platform GPL24247
Summary
Understanding prostate response to castration and androgen receptor signaling inhibitors (ARSI) is critical to improving long-term prostate cancer (PCa) patient survival. We use a multi-omics approach on 229,794 single cells to create a mouse single-cell reference atlas better suited to interpreting mouse prostate biology and castration response. Our reference atlas refines single-cell annotations and provides chromatin context, which, when coupled with mouse lineage tracing demonstrates that the castration-resistant luminal cells are distinct from the pre-existent urethra- proximal stem/progenitor cells.
Published in
Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells
Kirk JS, Wang J, Long M et al. · Cell stem cell 2024 · PMID 38878775 · doi:10.1016/j.stem.2024.05.008
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Also filed as BioProject PRJNA1061059 and SRA study SRP481681. Searching any of these in the dataset finder brings you back here.

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