GEO series
C. difficile's proline reductase harnesses host and commensal factors to drive efficient metabolism and progression to disease. Mono-association.
GSE252555
Mus musculus
Expression profiling by high throughput sequencing
26 samples
2026/06/09
GPL24247
Summary
Gnotobiotic mice were mono-colonized with either the wild-type Clostridioides difficile ATCC 43255 strain or the proline reductase mutant (ΔprdB) of the ATCC 43255 strain. Cecal contents were collected and underwent RNASeq at the timepoints indicated below for pathway enrichment and transcritpmic analyses. Metatranscriptomic sequence processing was carried out as in Girinathan, et al, 2021 (PMID: 34637781)
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