GEO series
Cardiomyocyte specific RXFP1-overexpression protects Relaxin-independently from pressure-overload induced cardiac dysfunction
GSE252607
Mus musculus
Expression profiling by high throughput sequencing
30 samples
2024/05/23
GPL23479
Summary
Aim was to investigate the effect of cardiomyocyte-specific expression of the human Relaxin Family Peptide Receptor 1 (RXFP1) in a mouse model of pressure-overload induced cardiac dysfunction (TAC). Mice overexpressing the hRXFP1 receptor (or non-transgenic controls) underwent TAC (or Sham) surgery and were followed up for 8 weeks. Heart was removed and RNA isolated from left ventricle to perform bulk RNAseq.
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Paper (PMID 38768763) ↗
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