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Determination of the tumor microenvironment remodeling by KRAS targeted therapy in pancreatic cancer

GSE252834 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2024/10/09 Platform GPL19057
Summary
Oncogenic KRAS is now recognized as a viable target for drug intervention; nevertheless, the efficacy of KRAS-targeted therapy is impeded by various resistance mechanisms. The intricate interplay between cancer cells and the cells within the tumor microenvironment (TME) actively contributes to the mutual promotion of resistance to KRAS-targeted therapies. To discern specific cell populations orchestrating tumor responses in pancreatic ductal adenocarcinoma (PDAC), we conducted single-cell RNA sequencing (scRNA-seq) on spontaneous tumors obtained from genetically engineered mouse models. This analysis was performed both before and after the inhibition or genetic ablation of KRAS, shedding light on the dynamic changes occurring at the single-cell level.
Published in
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer
Deng D, Begum H, Liu T et al. · The Journal of experimental medicine 2024 · PMID 39432061 · doi:10.1084/jem.20240766
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Also filed as BioProject PRJNA1062794 and SRA study SRP482775. Searching any of these in the dataset finder brings you back here.

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