Periodic Heat Waves-induced neuronal etiology in the elderly is mediated by Gut-Liver-Brain axis: A Transcriptome Profiling Approach
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Brain Control vs 3 × Brain Heat Stress vs 3 × Liver Control vs 3 × Liver Heat StressGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Periodic heat waves-induced neuronal etiology in the elderly is mediated by gut-liver-brain axis: a transcriptome profiling approachScientific reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252887_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1062909 and SRA study SRP482780. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8009830 Brain Control_1 Brain Control
- GSM8009831 Brain Control_2 Brain Control
- GSM8009832 Brain Control_3 Brain Control
- GSM8009833 Brain Heat Stress_1 Brain Heat Stress
- GSM8009834 Brain Heat Stress_2 Brain Heat Stress
- GSM8009835 Brain Heat Stress_3 Brain Heat Stress
- GSM8009836 Liver Control_1 Liver Control
- GSM8009837 Liver Control_2 Liver Control
- GSM8009838 Liver Control_3 Liver Control
- GSM8009839 Liver Heat Stress_1 Liver Heat Stress
- GSM8009840 Liver Heat Stress_2 Liver Heat Stress
- GSM8009841 Liver Heat Stress_3 Liver Heat Stress
- GSE327880 Neuronal activation triggers rapid biphasic FMRP-mediated translational control linking synaptic and nuclear regulation 51 samples shares neuronal, mediated
- GSE275917 Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation [ChIP-seq] 17 samples shares neuronal, mediated
- GSE306458 ACVR1-mediated glycolytic reprogramming promotes histone lactylation and neuronal pyroptosis in neuropathic pain {ChIP-seq] 12 samples shares neuronal, mediated
- GSE254996 ACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [RNA-seq] 98 samples shares neuronal
- GSE277512 Neuronal development shapes activity-dependent gene expression profiles in a stimulus-specific manner 55 samples shares neuronal
- GSE250570 RNA-seq analysis of neuronal differentiation of KAT6A/B knockout mouse embryonic stem cells 48 samples shares neuronal
- GSE272272 Changes in the astrocyte translatome induced by developmental ethanol mediate dysregulation of neuronal development: role of the extracellular matrix and relevance to Fetal Alcohol Spectrum Disorders 48 samples shares neuronal
- GSE312903 Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing [snRNA-seq, ssRNA-seq] 47 samples shares neuronal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.