Changes in the astrocyte translatome induced by developmental ethanol mediate dysregulation of neuronal development: role of the extracellular matrix and relevance to Fetal Alcohol Spectrum Disorders
RNA-seq (gene expression) · mouse · 48 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 48 samples: 48 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Astrocyte Extracellular Matrix Modulates Neuronal Dendritic DevelopmentGlia · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272272_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1135994. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 48 sample titles: 48 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8397582 IP, Female, Control, A-IP
- GSM8397583 IP, Female, Control, B-IP
- GSM8397584 IP, Female, Control, C-IP
- GSM8397585 IP, Male, Control, D-IP
- GSM8397586 IP, Male, Control, E-IP
- GSM8397587 IP, Female, EtOH, F-IP
- GSM8397588 IP, Female, EtOH, G-IP
- GSM8397589 IP, Female, EtOH, H-IP
- GSM8397590 IP, Male, EtOH, I-IP
- GSM8397591 IP, Male, EtOH, J-IP
- GSM8397592 IP, Male, EtOH, K-IP
- GSM8397593 IP, Female, Control, L-IP
- GSM8397594 IP, Female, EtOH, M-IP
- GSM8397595 IP, Male, EtOH, N-IP
- GSM8397596 IP, Female, Control, O-IP
- GSM8397597 IP, Male, Control, P-IP
- GSM8397598 IP, Male, Control, Q-IP
- GSM8397599 IP, Female, EtOH, R-IP
- GSM8397600 IP, Male, EtOH, T-IP
- GSM8397601 IP, Female, Control, U-IP
- GSM8397602 IP, Male, Control, V-IP
- GSM8397603 IP, Male, Control, W-IP
- GSM8397604 IP, Female, EtOH, X-IP
- GSM8397605 IP, Male, EtOH, Y-IP
- GSM8397606 input, Female, Control, 1-input
- GSM8397607 input, Male, EtOH, 2-input
- GSM8397608 input, Female, Control, A-input
- GSM8397609 input, Female, Control, B-input
- GSM8397610 input, Female, Control, C-input
- GSM8397611 input, Male, Control, D-input
- GSM8397612 input, Male, Control, E-input
- GSM8397613 input, Female, EtOH, F-input
- GSM8397614 input, Female, EtOH, G-input
- GSM8397615 input, Female, EtOH, H-input
- GSM8397616 input, Male, EtOH, I-input
- GSM8397617 input, Male, EtOH, J-input
- GSM8397618 input, Male, EtOH, K-input
- GSM8397619 input, Female, Control, L-input
- GSM8397620 input, Female, EtOH, M-input
- GSM8397621 input, Male, EtOH, N-input
+ 8 more — browse all 48 samples with per-sample file links →
- GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples shares astrocyte, neuronal
- GSE240857 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner[RNA-Seq] 29 samples shares astrocyte, neuronal
- GSE328106 Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy [Astrocyte_MACS] 23 samples shares astrocyte, neuronal
- GSE288733 Neuronal conversion of pre-labeled astrocyte using adeno-asociated viruses in vivo 18 samples shares astrocyte, neuronal
- GSE330617 Transcriptomic profiling of astrocytes under three extracellular acidification conditions 12 samples shares extracellular, astrocyte
- GSE306265 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity 106 samples shares astrocyte, neuronal
- GSE240860 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner 54 samples shares astrocyte, neuronal
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares astrocyte, neuronal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.