GEO series
TDP-43 nuclear loss in FTD-ALS causes widespread alternative polyadenylation
GSE252892
Homo sapiens
Expression profiling by high throughput sequencing; Other
12 samples
2025/11/20
GPL30173
Summary
In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B), providing evidence that alternative polyadenylation is a new facet to TDP-43 pathology.
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Paper (PMID 41120750) ↗
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