BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 34 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 34 samples: 28 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutationsBlood cancer journal · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252938_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1063269 and SRA study SRP482915. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 34 sample titles: 28 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8010532 MOLM13 Control 1
- GSM8010533 MOLM13 Control 2
- GSM8010534 MOLM13 100 nM FHD-286 1
- GSM8010535 MOLM13 100 nM FHD-286 2
- GSM8010536 MOLM13 Bulk RNA Control 1
- GSM8010537 MOLM13 Bulk RNA Control 2
- GSM8010538 MOLM13 Bulk RNA Control 3
- GSM8010539 MOLM13 Bulk RNA 100 nM FHD-286 1
- GSM8010540 MOLM13 Bulk RNA 100 nM FHD-286 2
- GSM8010541 MOLM13 Bulk RNA 100 nM FHD-286 3
- GSM8010542 MOLM13, Control, H3K27Ac
- GSM8010543 MOLM13, 100 nM FHD-286, H3K27Ac
- GSM8010544 MOLM13, Control, BRG1
- GSM8010545 MOLM13, 100 nM FHD-286, BRG1
- GSM8010546 MOLM13 Control, input
- GSM8010547 MOLM13, 100 nM FHD-286, input
- GSM8010548 DF16835, Control, BRM
- GSM8010549 DF16835, 100 nM FHD-286, BRM
- GSM8010550 DF16835, Control, H3K27Ac
- GSM8010551 DF16835, 100 nM FHD-286, H3K27Ac
- GSM8010552 DF16835, Control, input
- GSM8010553 DF16835, 100 nM FHD-286, input
- GSM8010554 AML323 Control scATAC Seq
- GSM8010555 AML323 100 nM FHD-286 scATAC Seq
- GSM8010556 AML336 Control scATAC Seq
- GSM8010557 AML336 100 nM FHD-286 scATAC Seq
- GSM8010558 AML340 Control scATAC Seq
- GSM8010559 AML340 100 nM FHD-286 scATAC Seq
- GSM8010560 AML323 Control scRNA Seq
- GSM8010561 AML323 100 nM FHD-286 scRNA Seq
- GSM8010562 AML336 Control scRNA Seq
- GSM8010563 AML336 100 nM FHD-286 scRNA Seq
- GSM8010564 AML340 Control scRNA Seq
- GSM8010565 AML340 100 nM FHD-286 scRNA Seq
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing · shares aml
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing
- GSE319092 Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and BET Synergy in AML Stem-like Cells 135 samples shares aml, bet
- GSE330843 The CRAC channel inhibitor Auxora interrupts inflammatory circuits between alveolar macrophages and T cells in patients with viral pneumonia 88 samples shares bet, inhibitor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.