GEO series
Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients
GSE253006
Homo sapiens
Expression profiling by high throughput sequencing
23 samples
2025/05/19
GPL18573
Summary
The variability and unpredictability of drug efficacy in ulcerative colitis (UC) patients, including tofacitinib, an oral JAK1 and JAK3 inhibitor, remains a perplexing reality. Here, we use single-cell RNA sequencing (scRNA-seq) analysis of intestinal cells from UC patients receiving tofacitinib to identify the cellular subsets and genes involved in the response and/or resistance to tofacitinib.
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Paper (PMID 40320713) ↗
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